Medium Sized Arteries (MSA-WG)

Clinical Trials/Observational Studies

Clinical trials and observational studies are important for advancing medical knowledge and improving patient care. Clinical trials are essential for evaluating the safety and effectiveness of new treatments, while observational studies provide valuable insights into the natural history of diseases and risk factors.

The Angiotensin II Receptor Blockade in Vascular Ehlers Danlos Syndrome (ARCADE) trial is a  randomized, double blind, placebo controlled trial that compares the administration of the Ang II type I receptor blocker (ARB) – irbesartan- to placebo over a 2-year period in vEDS patients with the main objective to reduce the incidence of both symptomatic and asymptomatic vascular events. The study started in January 2016 and ended February 19, 2020.


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