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April 10 2024

Call for Applications: Improving Understanding of Disease Mechanisms of PTEN Harmartoma Tumour Syndrome (PHTS)

PTEN Research Call for Applications 2024

The PTEN Research Foundation has launched a targeted call for applications, aiming to deepen the scientific community’s understanding of PTEN Harmatoma Tumour Syndrome (PHTS) disease mechanisms. This significant funding opportunity is designed to support innovative research projects that could potentially lead to novel therapeutic options for PHTS patients.

PHTS, a rare genetic condition caused by mutations in the PTEN gene, manifests in a diverse array of symptoms across multiple organs and significantly increases cancer risk. Despite its complexity, treatment options remain limited, underscoring the urgent need for advanced research in this area.

What the Funding Entails

The Foundation is offering up to £220,000 for research projects lasting 2-3 years. These projects should utilize the latest scientific tools, including newly developed PHTS patient-derived induced pluripotent stem cells (iPSCs) available from a US-based biorepository. These iPSCs are key to understanding the cellular behaviors at play in PHTS under various genetic conditions.

Eligibility and Application Details

Eligibility extends globally to researchers holding an MD or PhD affiliated with recognized academic or clinical research institutions. Interested applicants should submit a Project Proposal by June 28, 2024, and a Full Application by October 4, 2024. Successful candidates will be notified by the end of February 2025.

A Focus on Non-Malignant Manifestations of PHTS

This call specifically seeks to fund research exploring the non-cancerous effects of PHTS, such as neurodevelopmental delays and vascular anomalies. Projects that offer a clear translational pathway to clinical applications are highly encouraged, promising not only to advance our understanding but also to improve patient outcomes significantly.

The PTEN Research Foundation emphasizes the importance of collaborative and multi-center research proposals to foster diverse scientific perspectives and richer outcomes. Researchers lacking specific expertise in PHTS or PTEN are encouraged to involve collaborators with relevant experience.

For additional details on the iPSCs, application forms, or any other inquiries, researchers can contact the Foundation at research@ptenresearch.org. Detailed information about the Foundation’s strategy and the specific requirements for the funding can be found here.

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