Pills of Knowledge (PoK)
Pills of Knowledge (PoK) are defined as short single video lessons (of approximately 3-5 minutes long) in which an expert talks about a specific topic that has been selected and validated by the Rare Disease Working Groups (RDWGs).
This educational video presents the NOTCH3-SVD staging system, a new framework designed to classify the severity of CADASIL and other NOTCH3-related small vessel diseases. Developed by researchers at Leiden University Medical Center (LUMC) in collaboration with international experts, the system defines nine disease stages using MRI findings, lacune count, and key clinical features.
The staging approach offers a clearer understanding of disease progression and supports more consistent clinical care and research. The original framework is available through LUMC, and the full scientific publication is accessible in JAMA Neurology.
The video was developed and validated by the VASCERN Neurovascular Diseases Working Group to to provide a clear, accessible educational resource for healthcare professionals.
This short expert video, recorded at the International Krupp Symposium on Juvenile Stroke (14–15 March 2025, Alfried Krupp Hospital, Essen), focuses on the pathophysiology of Moyamoya Angiopathy.
The symposium gathered leading clinicians and researchers from across Europe and internationally to discuss advances in juvenile stroke and rare cerebrovascular diseases. Within this context, the session provides a concise scientific overview of how Moyamoya Angiopathy develops and why early detection and specialised management are essential.
This clip offers a clear, accessible summary suitable for healthcare professionals, trainees and anyone looking to deepen their understanding of Moyamoya Angiopathy.
This video has been validated by the VASCERN Neurovascular Diseases Working Group.
This short video, recorded at the International Krupp Symposium on Juvenile Stroke (14–15 March 2025, Alfried Krupp Hospital, Essen), provides an overview of Moyamoya Angiopathy in Europe. Presented in German, it forms part of a scientific programme dedicated to improving understanding of juvenile stroke and its underlying causes.
The symposium brought together leading experts from across Europe and beyond—including Canada, Greece, France, the Netherlands, Switzerland and Germany—to discuss current knowledge on rare cerebrovascular diseases. With a focus on young patients, the event highlighted the importance of early recognition, accurate diagnosis and specialised care in conditions such as Moyamoya Angiopathy.
This clip offers viewers a concise insight into how Moyamoya Angiopathy is perceived, diagnosed and managed within the European context.
This video was validated by the VASCERN Neurovascular Diseases Working Group.