Clinical Practice Guidelines (CPGs) adopted
The Heritable Thoracic Aortic Diseases Working Group (HTAD-WG) follows (and have generated) existing (national and international) guidelines. The guidelines reflect the latest scientific evidence and are regularly reviewed and updated to ensure they remain up-to-date.
Fabien Praz, Michael A Borger, Jonas Lanz, Mateo Marin-Cuartas, Ana Abreu, Marianna Adamo, Nina Ajmone Marsan, Fabio Barili, Nikolaos Bonaros, Bernard Cosyns, Ruggero De Paulis, Habib Gamra, Marjan Jahangiri, Anders Jeppsson, Robert J M Klautz, Benoit Mores, Esther Pérez-David, Janine Pöss, Bernard D Prendergast, Bianca Rocca, Xavier Rossello, Mikio Suzuki, Holger Thiele, Christophe Michel Tribouilloy, Wojtek Wojakowski, ESC/EACTS Scientific Document Group , 2025 ESC/EACTS Guidelines for the management of valvular heart disease: Developed by the task force for the management of valvular heart disease of the European Society of Cardiology (ESC) and the European Association for Cardio-Thoracic Surgery (EACTS), European Heart Journal, Volume 46, Issue 44, 21 November 2025, Pages 4635–4736, https://doi.org/10.1093/eurheartj/ehaf194
Julie De Backer, Kristina H Haugaa, Nina Eide Hasselberg, Michèle de Hosson, Margarita Brida, Silvia Castelletti, Matthew Cauldwell, Elisabetta Cerbai, Lia Crotti, Natasja M S de Groot, Mette-Elise Estensen, Eva S Goossens, Bernhard Haring, Donata Kurpas, Carmel M McEniery, Sanne A E Peters, Amina Rakisheva, Antonia Sambola, Oliver Schlager, Florian S Schoenhoff, Tommaso Simoncini, Françoise Steinbach, Isabella Sudano, Lorna Swan, Anne Marie Valente, ESC Scientific Document Group , 2025 ESC Guidelines for the management of cardiovascular disease and pregnancy: Developed by the task force on the management of cardiovascular disease and pregnancy of the European Society of Cardiology (ESC)
Endorsed by the European Society of Gynecology (ESG), European Heart Journal, Volume 46, Issue 43, 14 November 2025, Pages 4462–4568, https://doi.org/10.1093/eurheartj/ehaf193
Developed by the task force on the management of peripheral arterial and aortic diseases of the European Society of Cardiology (ESC). Endorsed by the European Association for Cardio-Thoracic Surgery (EACTS), the European Reference Network on Rare Multisystemic Vascular Diseases (VASCERN), and the European Society of Vascular Medicine (ESVM).
Summary: These guidelines address PAAD, updating and merging the 2017 peripheral arterial diseases and 2014 aortic diseases guidelines. The focus is primarily on atherosclerotic arterial diseases, but they also address some non-atherosclerotic genetic conditions.
Authors: Mazzolai L, Teixido-Tura G, Lanzi S, Boc V, Bossone E, Brodmann M, Bura-Rivière A, De Backer J, Deglise S, Della Corte A, Heiss C, Kałużna-Oleksy M, Kurpas D, McEniery CM, Mirault T, Pasquet AA, Pitcher A, Schaubroeck HAI, Schlager O, Sirnes PA, Sprynger MG, Stabile E, Steinbach F, Thielmann M, van Kimmenade RRJ, Venermo M, Rodriguez-Palomares JF; ESC Scientific Document Group.
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Evangelista A, Flachskampf FA, Erbel R, Antonini-Canterin F, Vlachopoulos C, Rocchi G, Sicari R, Nihoyannopoulos P, Zamorano J; European Association of Echocardiography; Document Reviewers:; Pepi M, Breithardt OA, Plonska-Gosciniak E. Echocardiography in aortic diseases: EAE recommendations for clinical practice. Eur J Echocardiogr. 2010 Sep;11(8):645-58. doi: 10.1093/ejechocard/jeq056. Erratum in: Eur J Echocardiogr. 2011 Aug;12(8):642. PMID: 20823280.
Grabenwöger M, Alfonso F, Bachet J, Bonser R, Czerny M, Eggebrecht H, Evangelista A, Fattori R, Jakob H, Lönn L, Nienaber CA, Rocchi G, Rousseau H, Thompson M, Weigang E, Erbel R. Thoracic Endovascular Aortic Repair (TEVAR) for the treatment of aortic diseases: a position statement from the European Association for Cardio-Thoracic Surgery (EACTS) and the European Society of Cardiology (ESC), in collaboration with the European Association of Percutaneous Cardiovascular Interventions (EAPCI). Eur Heart J. 2012 Jul;33(13):1558-63. doi: 10.1093/eurheartj/ehs074. Epub 2012 May 4. PMID: 22561257.
Goldstein SA, Evangelista A, Abbara S, Arai A, Asch FM, Badano LP, Bolen MA, Connolly HM, Cuéllar-Calàbria H, Czerny M, Devereux RB, Erbel RA, Fattori R, Isselbacher EM, Lindsay JM, McCulloch M, Michelena HI, Nienaber CA, Oh JK, Pepi M, Taylor AJ, Weinsaft JW, Zamorano JL, Dietz H, Eagle K, Elefteriades J, Jondeau G, Rousseau H, Schepens M. J Am Soc Echocardiogr. 2015 Feb;28(2):119-82. doi: 10.1016/j.echo.2014.11.015. PMID: 25623219.
Baumgartner H, De Backer J, Babu-Narayan SV, Budts W, Chessa M, Diller GP, Lung B, Kluin J, Lang IM, Meijboom F, Moons P, Mulder BJM, Oechslin E, Roos-Hesselink JW, Schwerzmann M, Sondergaard L, Zeppenfeld K; ESC Scientific Document Group.Eur Heart J. 2020 Aug 29:ehaa554. doi: 10.1093/eurheartj/ehaa554. Online ahead of print.PMID: 32860028
Summary: This CUGC intends to give guidance regarding molecular genetic testing in patients with thoracic aortic aneurysm and dissection. It includes genes associated with non-syndromic and syndromic conditions.
Authors: Arslan-Kirchner M, Arbustini E, Boileau C, Charron P, Child AH, Collod-Beroud G, De Backer J, De Paepe A, Dierking A, Faivre L, Hoffjan S, Jondeau G, Keyser B, Loeys B, Mayer K, Robinson PN, Schmidtke J.
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Summary: These Ghent criteria, comprising a set of major and minor manifestations in different body systems, have proven to work well since with improving molecular techniques, confirmation of the diagnosis is possible in over 95% of patients. However, concerns with the current nosology are that some of the diagnostic criteria have not been sufficiently validated, are not applicable in children or necessitate expensive and specialised investigations.
Authors: Loeys BL, Dietz HC, Braverman AC, Callewaert BL, De Backer J, Devereux RB, Hilhorst-Hofstee Y, Jondeau G, Faivre L, Milewicz DM, Pyeritz RE, Sponseller PD, Wordsworth P, De Paepe AM.